Stimulate & Renew A unique and highly potent form of microencapsulated Retinol designed to dramatically renew the skin’s appearance. Cosmedix Refine RX is designed with the highest concentration of our exclusive microencapsulated Retinol Complex (12%) to diminish the appearance of fine lines and wrinkles. L-Sodium Lactate binds moisture to help support irritated skin, while Chirally Correct L-Proline, a vital amino acid, provides key benefits for healthy skin.